Stephen Hawking (Reuters/Francois Lenoir)

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The Simpsons managed to tempt a bona fide genius to Springfield in season 10, with the famous synthesized voice of theoretical physicist and cosmologist (or, as Homer describes him, Lisa's "robot buddy") Stephen Hawking making one of the most critically acclaimed guest appearances in the show's history in the episode 'They Saved Lisa's Brain'.

Hawking's cameo was so successful that he went on to appear on the show a further three times.