Danny DeVito (Reuters/Phil McCarten)

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Diminutive actor Danny DeVito was one of the first big name guest stars to appear on The Simpsons, playing Homer's long-lost half brother 'Uncie' Herb Powell in the show's second season.

DeVito is not the only star to play a long-lost family member in the show: Glenn Close has also appeared Homer's estranged mother Mona on three seperate occasions.